Towards seizure onset zone localisation for neuronavigation in epilepsy surgery

Seminar/Forum

Towards seizure onset zone localisation for neuronavigation in epilepsy surgery

Boardroom
Centre for Neural Engineering
203 Bouverie St, Carlton

Map

More information

grayden@unimelb.edu.au

Biomedical Engineering Seminar

When one types “epilepsy” in the Google window the statement “Treatment can help, but this condition can't be cured” appears. This is not true, as it is well known that precisely targeted surgery is a curative treatment. Why is then surgical treatment of epilepsy “arguably the most underutilised of all proven effective therapeutic interventions in the field of medicine”. The catch is in “precisely targeted” - clinicians are often unable to characterise epileptic activity of the brain and identify appropriate resection regions with sufficient accuracy to proceed with surgery.

In this seminar I will discuss work in progress (conducted in collaboration with Boston Children’s Hospital) towards developing methods to precisely and reliably locate seizure onset zones (SOZ) and visualise them with respect to pre-operative brain anatomy in a system to improve intra-operative visualisation, navigation and monitoring. The approach consists of taking a pre-operative 3D MRI; implanting intracranial electrodes (but maybe a Stentrode?); taking a CT with electrodes implanted; registering pre-operative 3D MRI onto a CT with implanted electrodes; and finally solving inverse electric field propagation problem to identify SOZ.

Presenter

  • Professor Karol Miller
    Professor Karol Miller, University of Western Australia