Towards seizure onset zone localisation for neuronavigation in epilepsy surgery
Centre for Neural Engineering
203 Bouverie St, Carlton
Biomedical Engineering Seminar
When one types “epilepsy” in the Google window the statement “Treatment can help, but this condition can't be cured” appears. This is not true, as it is well known that precisely targeted surgery is a curative treatment. Why is then surgical treatment of epilepsy “arguably the most underutilised of all proven effective therapeutic interventions in the field of medicine”. The catch is in “precisely targeted” - clinicians are often unable to characterise epileptic activity of the brain and identify appropriate resection regions with sufficient accuracy to proceed with surgery.
In this seminar I will discuss work in progress (conducted in collaboration with Boston Children’s Hospital) towards developing methods to precisely and reliably locate seizure onset zones (SOZ) and visualise them with respect to pre-operative brain anatomy in a system to improve intra-operative visualisation, navigation and monitoring. The approach consists of taking a pre-operative 3D MRI; implanting intracranial electrodes (but maybe a Stentrode?); taking a CT with electrodes implanted; registering pre-operative 3D MRI onto a CT with implanted electrodes; and finally solving inverse electric field propagation problem to identify SOZ.
Professor Karol Miller, University of Western Australia
Professor Karol Miller
University of Western Australia
Karol Miller studied Applied Mechanics and received PhD in Robotics from Warsaw University of Technology in 1994, and Doctorate of Science (Habilitation) in Biomechanics from the Polish Academy of Sciences in 2003. He has been with UWA for over twenty years. In 2002 he established the Intelligent Systems for Medicine Laboratory. ISML’s mission is to work towards improving clinical outcomes through appropriate use of technology. It runs exciting research projects funded by the Australian Research Council, the National Health and Medical Research Council (Australia), the National Institute of Health (USA) and other national and international agencies. The overall objective of his research is to help creating methods and tools which will enable a new exciting era of personalised medicine. He is best known for his work on biomechanics of soft tissues. His current research interests include computational biomechanics for medicine and numerical methods, with applications to surgical simulation, imageguided surgery and, surprise, geomechanics. Karol has served on numerous NHMRC grant panels. He is also a member of the ARC College of Experts. His research and teaching have been recognised by multiple awards, including the Humboldt Research Award, NVIDIA GPU Computing Champion Award, the Simulation Industry Association Australia Award, the Sir Charles Julius Medal, the Polish Prime Minister Award, the UWA Faculty of Engineering Computing and Mathematics Teaching Award and the UWA Student Guild Choice Award.