Small meets smaller: nanomaterial-microbe crosstalk - physicochemical principles and (patho)biological consequences
Pathogenic microorganism can cause severe diseases. Also, scientific and medical interest in the human microbiome, defined as the sum of all microbial organisms residing inside the body, has increased dramatically. Notably, the infection paths of pathogenic microorganism overlap with major entry routes for nanoparticles (NPs), occurring during environmental exposure or deliberate medical applications. For example, besides NPs, the air we breathe is also filled with a high number of fungal spores, originating from a variety of fungal species. Hence, it is surprising that the interaction of NPs with (pathogenic) microorganism and its (patho)biological consequences have not yet been investigated in detail.
As the physico-chemical characteristics of NPs (co)define their behaviors and (patho)biological activity in physiological systems, we studied a library of various model NPs widely varying in size, material, shape, and surface functionalization. The interaction of NPs with different microorganisms as well as the impact of NPs on microorganism-host cell responses was investigated by comprehensive analytical approaches.
We report how different microorganisms interact with NPs, discuss the underlying physico-chemical principles, the impact of the biomolecule corona, and demonstrate how these interactions can impact the (patho)biological outcome and fate of exposure of the human host to both, NPs and microorganisms. We expect that the identified mechanism will be of biomedical and toxicological relevance for the field.
Professor Roland H. Stauber , University Medical Center of Mainz
Professor Roland H. Stauber
University Medical Center of Mainz
Roland H. Stauber received his Ph.D. from the University of Würzburg in biology and did his postdoctoral work at the National Cancer Center (NCI) in the US. In 2001 he became an Assistant Professor of Tumour Biology at the University of Frankfurt and was appointed in 2006 as a full professor for Nanobiomedicine at the University Hospital in Mainz. Prof Stauber’s research activity has resulted in numerous national and international collaborations, and he has published numerous papers, including leading journals such as Nature Nanotechnology (Total publications: 139 papers; total citations: 7012 times; hIndex43). In 2010 he received the Alexander Karl Award for Cancer Research and is a visiting Professor at the Chinese Academy of Sciences. As such he interacts extensively with clinicians, pathologists, pharmacologists as well as patient organizations. His group is well known in the fields of nanobiomedicine, nanotoxicology, cancer cell biology, and academic drug development, and received about EUR 23 million in competitive research grants. He is managing the highthroughput microscopy based screening platform, coordinates the research initiative Chemical (Nano)BioMedicine, and serves as a referee for international funding organizations and journals.