Small meets smaller: nanomaterial-microbe crosstalk - physicochemical principles and (patho)biological consequences

Seminar/Forum

Small meets smaller: nanomaterial-microbe crosstalk - physicochemical principles and (patho)biological consequences

Theatre G20
Building 165

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More information

T: 8344 8324

wei.peng@unimelb.edu.au

Pathogenic microorganism can cause severe diseases. Also, scientific and medical interest in the human microbiome, defined as the sum of all microbial organisms residing inside the body, has increased dramatically. Notably, the infection paths of pathogenic microorganism overlap with major entry routes for nanoparticles (NPs), occurring during environmental exposure or deliberate medical applications. For example, besides NPs, the air we breathe is also filled with a high number of fungal spores, originating from a variety of fungal species. Hence, it is surprising that the interaction of NPs with (pathogenic) microorganism and its (patho)biological consequences have not yet been investigated in detail.

As the physico-chemical characteristics of NPs (co)define their behaviors and (patho)biological activity in physiological systems, we studied a library of various model NPs widely varying in size, material, shape, and surface functionalization. The interaction of NPs with different microorganisms as well as the impact of NPs on microorganism-host cell responses was investigated by comprehensive analytical approaches.

We report how different microorganisms interact with NPs, discuss the underlying physico-chemical principles, the impact of the biomolecule corona, and demonstrate how these interactions can impact the (patho)biological outcome and fate of exposure of the human host to both, NPs and microorganisms. We expect that the identified mechanism will be of biomedical and toxicological relevance for the field.

Presenter

  • Professor Roland H.  Stauber
    Professor Roland H. Stauber , University Medical Center of Mainz